LHYQ

Ans.
· In HPLC the mobile phase is a liquid whereas in Gas Chromatography the mobile phase or carrier is a gas. · HPLC is useful for analysis of samples which are liable to decompose at higher temperatures. GC involves high temperatures so compounds are stable at such temperatures. · Gas Chromatography is applied for analysis of volatile compounds whereas non volatile compounds can be easily analyzed on HPLC · Gas Chromatography cannot be used for analysis of high molecular weight molecules whereas HPLC has applications for separation and identification of very high molecular weight compounds · HPLC requires higher operating pressures than GC because liquids require higher pressures than gases for transport through the system · HPLC columns are short and wide in comparison to GC columns